History
Its use at low doses has been deemed acceptable by the American Food and Drug Administration (FDA) and several other countries.
Studies have found a much higher incidence of psychiatric disturbances (sometimes severe) with triazolam, even when using the lower doses of 0.125 mg. Clinical trials which Upjohn had withheld from publishing showed a very unfavourable risk benefit ratio with 9.9% of patients dropping out of one triazolam study versus 1.9% of trial subjects taking a comparison benzodiazepine, flurazepam. Another study not published by Upjohn found 12.2% of triazolam patients dropped out, again due to psychiatric adverse effects compared against 4.1% for flurazepam. A further study found that after only 3 weeks use of triazolam patients typically became markedly anxious. As a result of these studies, both published and unpublished, coming to light showing frequent severe psychiatric disturbances the United Kingdom and Brazil decided to ban triazolam.
According to one psychiatrist in the USA who has published numerous papers on hypnotic medications, the risk/benefit ratio of triazolam, even at low dosage, is so poor that he questioned if triazolam should remain on the market in the USA.
Read more about this topic: Triazolam
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