TTO is a three-letter abbreviation that may refer to:
- Time-trade-off
- Tactical Technology Office, a division of DARPA
- Technology Transfer Office
- Transtrachreal oxygen, as used during Jet ventilation
- Trinidad and Tobago
- Toontown Online
- Trailing throttle oversteer, also known as lift-off oversteer
- Tanker Take Over
- Twist-to-open razor, a type of safety razor (see mention under Gillette (brand))
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