UCS may refer to:
- Cisco Unified Computing System, a computing platform
- Civic Solidarity Union, a political party in Bolivia
- Kolej Bersatu Sarawak (UCS), an educational institution in Malaysia
- Uniform Color Scales, a color space developed by the Optical Society of America
- Uniform Communication Standard, an electronic commerce standard
- Uniform-cost search, an algorithm used to search a weighted graph
- Union of Concerned Scientists, a nonprofit advocacy organisation
- United Cigar Stores, an American tobacconist chain of the early 20th century
- United Communication Service, the largest cable operator in Bangladesh
- Univention Corporate Server, an operating and management system for IT infrastructure
- Universal Cartoon Studios, the animation and features division of Universal Studios
- Universal Character Set, a standard for character encoding
- Universal Charging Solution, a proposed standard for cell phone chargers
- University Campus Suffolk, a university based in Ipswich, Suffolk, United Kingdom
- University College School, a British public school situated in Hampstead, north west London
- University of Caxias do Sul, a university in Brazil
- Upper Clyde Shipbuilders, a now defunct amalgamation of shipbuilders of the River Clyde, Glasgow, Scotland