Uracil - Reactions

Reactions

Uracil readily undergoes regular reactions including oxidation, nitration, and alkylation. While in the presence of phenol (PhOH) and sodium hypochlorite (NaOCl), uracil can be visualized in the blue region of UV light. Uracil also has the capability to react with elemental halogens because of the presence of more than one strongly electron donating group.

Uracil readily undergoes addition to ribose sugars and phosphates to partake in synthesis and further reactions in the body. Uracil becomes uridine, uridine monophosphate (UMP), uridine diphosphate (UDP), uridine triphosphate (UTP), and uridine diphosphate glucose (UDP-glucose). Each one of these molecules is synthesized in the body and has specific functions.

When uracil reacts with anhydrous hydrazine, a first-order kinetic reaction occurs and the ring of uracil opens up. If the pH of the reaction increases to >10.5, the uracil anion forms, making the reaction go much slower. The same slowing of the reaction occurs if the pH decreases because of the protonation of the hydrazine. The reactivity of uracil is unchanged even if the temperature changes.

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