USP may refer to:
- Heckler & Koch USP pistol
- NUS University Scholars Programme
- Ultrashort pulse laser, a laser that emits ultrashort pulses of light, generally of the order of femtoseconds to hundreds of femtoseconds
- Ultraspiracle protein, a part of the ecdysone receptor
- Unique selling proposition, a marketing concept that was first proposed as a theory to explain a pattern among successful advertising campaigns of the early 1940s
- Unité Spéciale de la Police, a special unit of the Luxembourg Grand Ducal Police
- United States patent
- United States Pharmacopeia, an official public standards-setting authority for all prescription and over-the-counter medicines and other health care products manufactured or sold in the United States
- USP DI (United States Pharmacopeia Dispensing Information), a comprehensive drug information database that is available online through EBSCO Publishing as well as in two print editions:
- USP DI Volume I: Drug Information for the Health Care Professional
- USP DI Volume II: Advice for the Patient, Drug Information in Lay Language
- United States Pharmacopeia unit (USP unit), a standard dosage unit for a drug or vitamin; is equal to the international unit in most cases
- USP DI (United States Pharmacopeia Dispensing Information), a comprehensive drug information database that is available online through EBSCO Publishing as well as in two print editions:
- Universal Storage Platform, the brand name for an Hitachi Data Systems line of enterprise storage arrays
- University of São Paulo, a public university of the Brazilian state of São Paulo
- University of the Sciences in Philadelphia
- University of the South Pacific, a public university with a number of locations in Oceania
- U.S. Penitentiary
- USp (2n), the symplectic group
- USP Networks
- USS Saint Paul
- Utah State Prison, located in Draper, Utah, United States, about 20 miles southwest of Salt Lake City
- Uttama Seva Padakkama, a military decoration in Sri Lanka
- Unified settlement planning, a form of holistic planning model in India
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