Virginio is a given name, and may refer to:
- Virginio Cáceres (born 1962), Paraguayan footballer
- Virginio Colombo (1885-1927), Italian architect
- Virginio Ferrari (born 1952), Italian motorcycle racer
- Virginio Ferrari (artist) (21st century), Italian sculptor
- Virginio Livraghi (21st century), Italian comic strip artist and illustrator
- Virginio Orsini (circa 1434-1497), Italian condottiero
- Virginio Orsini (cardinal) (1615-1676), Italian cardinal
- Virginio Rognoni (born 1924), Italian politician
- Virginio Rosetta (1902-1975), Italian former football player
- Virginio Vespignani (1808-1882), Italian architect
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