Software
- Windows Vista, the line of Microsoft Windows client operating systems released in 2006 and 2007
- VistA, (Veterans Health Information Systems and Technology Architecture) a medical records system of the United States Department of Veterans Affairs and others worldwide
- VISTA (comparative genomics), software tools for genome analysis and genomic sequence comparisons
- VistaPro, and Vista, 3D landscape generation software for the Amiga and PC
- VIsualizing STructures And Sequences, bioinformatics software
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