VLB may mean:
- VLB Berlin (Versuch- u. Lehranstalt für Brauerei in Berlin) brewing school and trade organization in Berlin
- Volunteer Life Brigade, the forerunners of today Auxiliary Coastguard in the United Kingdom
- VESA Local Bus, a local bus based on the Intel 80486 CPU
- Viva La Bam, an MTV television series starring Bam Margera
- Victor-Lévy Beaulieu, a Québécois writer, playwright and editor
- Very Large Board, a large circuit board
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