Wis may refer to:
- Walsh Intermediate School, a middle school in Branford, Connecticut
- Washington International School, an international school in the District of Columbia
- Web information system
- Wedge imaging spectrometer, a type of imaging spectrometer
- Weizmann Institute of Science, a university and research institute in Rehovot, Israel
- West Island School, a British high school in Hong Kong, China
- Windhoek International School, an international school in Windhoek, Namibia
- WiS, the original name of the Vis pistol
- WIS, an NBC affiliate in South Carolina
- WIS International, an inventory and retail merchandising company formed with the merger of Washington Inventory Service and Western Inventory Service
- Wisconsin, a U.S. state
- Book of Wisdom, one of the deuterocanonical books of the Bible
- WISW, a radio station in Columbia, South Carolina which calls itself WIS
- WXBT, a radio station in Columbia, South Carolina once called WIS
- Waste Information Systems, a software company, based in Ireland, which develops systems for the waste management industry.