X Inactivation Center (XIC)
The Xist RNA gene consists of an X Inactivation Center (XIC), which plays a major role in Xist expression and X inactivation. The XIC is located on the q arm of the X chromosome (Xq13). XIC regulates Xist in cis X inactivation, where Tsix, an antisense of Xist, downregulates the expression of Xist. The Xist promoter of XIC is the master regulator of X inactivation. X inactivation plays a key role in dosage compensation.
Read more about this topic: XIST (gene)
Famous quotes containing the word center:
“Louise Bryant: I’m sorry if you don’t believe in mutual independence and free love and respect.
Eugene O’Neill: Don’t give me a lot of parlor socialism that you learned in the village. If you were mine, I wouldn’t share you with anybody or anything. It would be just you and me. You’d be at the center of it all. You know it would feel a lot more like love than being left alone with your work.”
—Warren Beatty (b. 1937)