Relationship With Diseases of The Eye
Several observational studies have connected high dietary intake of foods providing zeaxanthin with lower incidence of age-related macular degeneration (AMD), most notably the Age-Related Eye Disease study (AREDS). There is currently insufficient evidence to assess the effectiveness of dietary or supplemental antioxidants in treatment or primary prevention of ARMD, or the formation or progression of cataracts. Any benefit is more likely to be apparent in subpopulations of individuals exposed to high oxidative stress, such as heavy smokers or those with poor nutrition. In 2005, the US Food and Drug Administration rejected a Qualified Health Claims application by Xangold, citing insufficient evidence supporting the use of a zeaxanthin-containing supplement in prevention of AMD.
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