Fictional Characters
- Derek and Clive, controversial cult characters portrayed by Dudley Moore and Peter Cook
- Derek the dark green diesel, character from Thomas the Tank Engine
- Derek the Midget, character played by radio personality Shuli
- Derek the Sheep, eponymous character in a comic strip in the Beano
- Derek Almond, character in the graphic novel V for Vendetta
- Derek Bliss, character in Vampires: Los Muertos
- Derek Blunt, anthropomorphic hawk in Darkwing Duck
- Derek Branning, character in the BBC soap EastEnders
- Derek Conway, character in British TV series The Bill
- Derek the Dalmatian (also known as "Evil Derek the Dark Dalmatian"), from the 1970s BBC children's television series Olimar The Wondercat
- Derek Flint, eponymous character in Our Man Flint
- Derek Frye, character in the ABC soap opera All My Children
- Derek Harkinson, character in the BBC soap EastEnders
- Derek Hale, character in Teen Wolf
- Derek Haig, a character in Degrassi: The Next Generation
- Derek Jupiter, the lead singer of the fictional band "Iron Weasel" from I'm in the Band
- Derek Klivian, pilot in the Rogue Squadron from Star Wars
- Derek Morgan, senior special agent in Criminal Minds
- Derek Noakes, eponymous character in the comedy-drama pilot Derek, created, written and played by Ricky Gervais
- Derek O'Farrell, character in the British soap Brookside
- Derek Powers aka Blight, supervillain in the animated series Batman Beyond
- Derek Shepherd aka McDreamy, neurosurgeon in the American medical series Grey's Anatomy
- Derek Smalls, character in the spoof rockumentary This is Spinal Tap
- Derek Stevens, character in Saturday Night Live musical sketches
- Derek Stiles, character in the Trauma Center series of video games
- Derek Trotter, character in the TV comedy series Only Fools and Horses
- Derek Venturi, character in the Canadian TV show Life with Derek
- Derek Vinyard in American History X
- Derek Wheeler aka "Wheels", character in the Degrassi series
- Derek Wilton, character in the TV soap Coronation Street
- Derek Zoolander, eponymous character in the film Zoolander
- Prince Derek, Son of Queen Uberta, character in The Swan Princess
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