OSR can refer to:
- OSR#1, an industrial chelation agent which had been marketed as a dietary supplement to parents of children with autism
- Operational sex ratio, ratio of reproductively available males to females
- Ōban Star-Racers, an animated television series
- Ostrava-Mošnov International Airport, IATA airport code
- Owasippe Scout Reservation, a Boy Scout camp in Twin Lake, Michigan
- Old San Antonio Road, including the section labeled State Highway OSR (Texas)
- Operation Summer Rains, also known as the 2006 Israel–Gaza conflict
- Optical Solar Reflector, a radiator material for space craft
- Open Source Resistance, a website created by Trent Reznor for the Year Zero alternate reality game
- Ockanickon Scout Reservation, a Boy Scout resident camp in Bucks County, PA
- Om Sai Ram, another name for Shirdi_SAI
- Oilseed Rape
- Oversampling Ratio
- Old School Renaissance, a movement in table top role-playing games focusing on older games and retro-clones
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